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Innovative Technologies and Advanced Polymers in Topical Drug Delivery Systems
Topical drug delivery systems are continuously evolving through advanced excipient technologies designed to enhance transdermal permeability, stability, and patient compliance. Key innovations include the use of chemical permeation enhancers, such as sulfoxides and certain fatty acids, that temporarily reduce the skin’s barrier function to increase drug absorption across the stratum corneum. Furthermore, the development of 'smart polymers' that are responsive to external stimuli like temperature or pH is allowing for targeted and controlled drug release directly at the treatment site. The aesthetic quality of formulations is also receiving increased focus, with non-irritant emulsifiers and texture-enhancing agents being used to improve the feel and appeal of the product, which is crucial for maximizing patient adherence.